Positron emission tomographic imaging of the dopamine transporter with 11C‐WIN 35,428 reveals marked declines in mild Parkinson's disease
Identifieur interne : 002520 ( Main/Exploration ); précédent : 002519; suivant : 002521Positron emission tomographic imaging of the dopamine transporter with 11C‐WIN 35,428 reveals marked declines in mild Parkinson's disease
Auteurs : Frost [États-Unis] ; Annemie J. Rosier [États-Unis] ; Stephen G. Reich [États-Unis] ; Justin S. Smith [États-Unis] ; Michael D. Ehlers [États-Unis] ; Solomon H. Snyder [États-Unis] ; Hayden T. Ravert [États-Unis] ; Robert F. Dannals [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 1993-09.
Abstract
Parkinson's Disease (PD) is characterized by a selective loss of nigrostriatal dopaminergic neurons that results in a marked reduction of dopaminergic nerve terminals in the striatum. Recently, 11C‐WIN 35,428, a cocaine analogue that specifically labels the dopamine transporter, was developed and can be used to label dopaminergic nerve terminals in vivo by positron emission tomography. In healthy control subjects, binding of 11C‐WIN 35,428 is highest in the striatum. In addition, 2 symmetrical focal areas of low binding were observed in the midbrain. The cerebellum functioned as an appropriate region for nonspecific binding. The binding of 11C‐WIN 35,428 in patients with PD (Hoehn‐Yahr II) was compared with that in healthy control subjects by using the (region‐cerebellum)/cerebellum ratio for data acquired 34 to 82 minutes after injection. In control subjects, this ratio varied, at approximately 2, in the striatum. In patients with PD, binding in the posterior putamen was reduced by 78%, whereas the anterior putamen and the caudate nucleus showed a reduction of 59 and 39%, respectively. The reduction in 11C‐WIN 35,428 binding was highest in the midbrain (84%). The high specific/nonspecific binding ratio and the pronounced reduction in binding in mild PD may permit detection of even earlier stages of PD or presymptomatic individuals with dopaminergic cell loss.
Url:
DOI: 10.1002/ana.410340331
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Positron emission tomographic imaging of the dopamine transporter with 11C‐WIN 35,428 reveals marked declines in mild Parkinson's disease</title>
<author><name sortKey="Frost" sort="Frost" uniqKey="Frost" last="Frost">Frost</name>
</author>
<author><name sortKey="Rosier, Annemie J" sort="Rosier, Annemie J" uniqKey="Rosier A" first="Annemie J." last="Rosier">Annemie J. Rosier</name>
</author>
<author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name>
</author>
<author><name sortKey="Smith, Justin S" sort="Smith, Justin S" uniqKey="Smith J" first="Justin S." last="Smith">Justin S. Smith</name>
</author>
<author><name sortKey="Ehlers, Michael D" sort="Ehlers, Michael D" uniqKey="Ehlers M" first="Michael D." last="Ehlers">Michael D. Ehlers</name>
</author>
<author><name sortKey="Snyder, Solomon H" sort="Snyder, Solomon H" uniqKey="Snyder S" first="Solomon H." last="Snyder">Solomon H. Snyder</name>
</author>
<author><name sortKey="Ravert, Hayden T" sort="Ravert, Hayden T" uniqKey="Ravert H" first="Hayden T." last="Ravert">Hayden T. Ravert</name>
</author>
<author><name sortKey="Dannals, Robert F" sort="Dannals, Robert F" uniqKey="Dannals R" first="Robert F." last="Dannals">Robert F. Dannals</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:876C7F4A4E3A974E0F4ABF67C8CAE02D592D441A</idno>
<date when="1993" year="1993">1993</date>
<idno type="doi">10.1002/ana.410340331</idno>
<idno type="url">https://api.istex.fr/document/876C7F4A4E3A974E0F4ABF67C8CAE02D592D441A/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001508</idno>
<idno type="wicri:Area/Main/Curation">001284</idno>
<idno type="wicri:Area/Main/Exploration">002520</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Positron emission tomographic imaging of the dopamine transporter with 11C‐WIN 35,428 reveals marked declines in mild Parkinson's disease</title>
<author><name sortKey="Frost" sort="Frost" uniqKey="Frost" last="Frost">Frost</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Radiology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rosier, Annemie J" sort="Rosier, Annemie J" uniqKey="Rosier A" first="Annemie J." last="Rosier">Annemie J. Rosier</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Radiology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neurology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Smith, Justin S" sort="Smith, Justin S" uniqKey="Smith J" first="Justin S." last="Smith">Justin S. Smith</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Radiology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ehlers, Michael D" sort="Ehlers, Michael D" uniqKey="Ehlers M" first="Michael D." last="Ehlers">Michael D. Ehlers</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Snyder, Solomon H" sort="Snyder, Solomon H" uniqKey="Snyder S" first="Solomon H." last="Snyder">Solomon H. Snyder</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ravert, Hayden T" sort="Ravert, Hayden T" uniqKey="Ravert H" first="Hayden T." last="Ravert">Hayden T. Ravert</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Radiology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dannals, Robert F" sort="Dannals, Robert F" uniqKey="Dannals R" first="Robert F." last="Dannals">Robert F. Dannals</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Radiology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Neurology</title>
<title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1993-09">1993-09</date>
<biblScope unit="volume">34</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="423">423</biblScope>
<biblScope unit="page" to="431">431</biblScope>
</imprint>
<idno type="ISSN">0364-5134</idno>
</series>
<idno type="istex">876C7F4A4E3A974E0F4ABF67C8CAE02D592D441A</idno>
<idno type="DOI">10.1002/ana.410340331</idno>
<idno type="ArticleID">ANA410340331</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's Disease (PD) is characterized by a selective loss of nigrostriatal dopaminergic neurons that results in a marked reduction of dopaminergic nerve terminals in the striatum. Recently, 11C‐WIN 35,428, a cocaine analogue that specifically labels the dopamine transporter, was developed and can be used to label dopaminergic nerve terminals in vivo by positron emission tomography. In healthy control subjects, binding of 11C‐WIN 35,428 is highest in the striatum. In addition, 2 symmetrical focal areas of low binding were observed in the midbrain. The cerebellum functioned as an appropriate region for nonspecific binding. The binding of 11C‐WIN 35,428 in patients with PD (Hoehn‐Yahr II) was compared with that in healthy control subjects by using the (region‐cerebellum)/cerebellum ratio for data acquired 34 to 82 minutes after injection. In control subjects, this ratio varied, at approximately 2, in the striatum. In patients with PD, binding in the posterior putamen was reduced by 78%, whereas the anterior putamen and the caudate nucleus showed a reduction of 59 and 39%, respectively. The reduction in 11C‐WIN 35,428 binding was highest in the midbrain (84%). The high specific/nonspecific binding ratio and the pronounced reduction in binding in mild PD may permit detection of even earlier stages of PD or presymptomatic individuals with dopaminergic cell loss.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Frost" sort="Frost" uniqKey="Frost" last="Frost">Frost</name>
</region>
<name sortKey="Dannals, Robert F" sort="Dannals, Robert F" uniqKey="Dannals R" first="Robert F." last="Dannals">Robert F. Dannals</name>
<name sortKey="Ehlers, Michael D" sort="Ehlers, Michael D" uniqKey="Ehlers M" first="Michael D." last="Ehlers">Michael D. Ehlers</name>
<name sortKey="Frost" sort="Frost" uniqKey="Frost" last="Frost">Frost</name>
<name sortKey="Ravert, Hayden T" sort="Ravert, Hayden T" uniqKey="Ravert H" first="Hayden T." last="Ravert">Hayden T. Ravert</name>
<name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name>
<name sortKey="Rosier, Annemie J" sort="Rosier, Annemie J" uniqKey="Rosier A" first="Annemie J." last="Rosier">Annemie J. Rosier</name>
<name sortKey="Smith, Justin S" sort="Smith, Justin S" uniqKey="Smith J" first="Justin S." last="Smith">Justin S. Smith</name>
<name sortKey="Snyder, Solomon H" sort="Snyder, Solomon H" uniqKey="Snyder S" first="Solomon H." last="Snyder">Solomon H. Snyder</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002520 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002520 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:876C7F4A4E3A974E0F4ABF67C8CAE02D592D441A |texte= Positron emission tomographic imaging of the dopamine transporter with 11C‐WIN 35,428 reveals marked declines in mild Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |